α v β 5 integrin Search Results


integrin α v β 5  (Human Protein Atlas)
90
Human Protein Atlas integrin α v β 5
ZIKV-LAV entry in human GBM cells is mediated by Axl and <t>integrin</t> α v β 5 . Evaluation of the effect of siRNA-mediated knockdown of either Axl or integrin α v β 5 gene on A – B viral entry in DBTRG ( A ) and T98G ( B ) cells; C – D protein expression of Axl ( C ) and integrin α v β 5 ( D ) on the cell surface; and E – F intracellular viral replication in DBTRG ( E ) and T98G ( F ) cells. SCR , scrambled siRNA. Int.α v β 5 , integrin α v β 5. Data are presented as mean ± SEM. Non-parametric Mann–Whitney test or Kruskal–Wallis test with Dunn’s post-hoc correction was used to compare groups. p -values are shown accordingly: * p < 0.05. ** p < 0.005, *** p < 0.001
Integrin α V β 5, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/integrin α v β 5/product/Human Protein Atlas
Average 90 stars, based on 1 article reviews
integrin α v β 5 - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier

Image Search Results


ZIKV-LAV entry in human GBM cells is mediated by Axl and integrin α v β 5 . Evaluation of the effect of siRNA-mediated knockdown of either Axl or integrin α v β 5 gene on A – B viral entry in DBTRG ( A ) and T98G ( B ) cells; C – D protein expression of Axl ( C ) and integrin α v β 5 ( D ) on the cell surface; and E – F intracellular viral replication in DBTRG ( E ) and T98G ( F ) cells. SCR , scrambled siRNA. Int.α v β 5 , integrin α v β 5. Data are presented as mean ± SEM. Non-parametric Mann–Whitney test or Kruskal–Wallis test with Dunn’s post-hoc correction was used to compare groups. p -values are shown accordingly: * p < 0.05. ** p < 0.005, *** p < 0.001

Journal: Journal of Translational Medicine

Article Title: Repurposing of Zika virus live-attenuated vaccine (ZIKV-LAV) strains as oncolytic viruses targeting human glioblastoma multiforme cells

doi: 10.1186/s12967-024-04930-4

Figure Lengend Snippet: ZIKV-LAV entry in human GBM cells is mediated by Axl and integrin α v β 5 . Evaluation of the effect of siRNA-mediated knockdown of either Axl or integrin α v β 5 gene on A – B viral entry in DBTRG ( A ) and T98G ( B ) cells; C – D protein expression of Axl ( C ) and integrin α v β 5 ( D ) on the cell surface; and E – F intracellular viral replication in DBTRG ( E ) and T98G ( F ) cells. SCR , scrambled siRNA. Int.α v β 5 , integrin α v β 5. Data are presented as mean ± SEM. Non-parametric Mann–Whitney test or Kruskal–Wallis test with Dunn’s post-hoc correction was used to compare groups. p -values are shown accordingly: * p < 0.05. ** p < 0.005, *** p < 0.001

Article Snippet: The Human Protein Atlas report that Axl and integrin β 5 are highly expressed in neuroprogenitor cells (NPC) but not in terminally differentiated neurons [ , ], indicating that the GBM selectivity of ZIKV-LAV infection is partly explained by differential Axl and integrin α v β 5 expression.

Techniques: Knockdown, Expressing, MANN-WHITNEY

Proposed model of human GBM cell death mediated by ZIKV-LAV infection. A – D General virus infection life cycle. A ZIKV-LAV enters human GBM cells through Axl and integrin α v β 5 cellular receptors. B The ZIKV-LAV genome is translated to express viral proteins and the viral genome is replicated. C The viral genome and viral proteins assemble the nucleoprotein in preparation for ( D ) release of progeny into the surroundings with concomitant viral incorporation of host cell membrane. E Cellular and viral proteins expressed during ZIKV-LAV infection are also responsible for cell death in human GBM. F – G cleavage of caspase-3 leads to non-lytic or non-inflammatory cell death by apoptosis; H – I cleavage of gasdermin-D (GSDMD) leads to the formation of membrane pore complexes that shuttles inflammatory IL-1β outside of the cells. GSDMD cleavage also leads to inflammasome activation and lytic and inflammatory cell death by pyroptosis. Image created with BioRender.com

Journal: Journal of Translational Medicine

Article Title: Repurposing of Zika virus live-attenuated vaccine (ZIKV-LAV) strains as oncolytic viruses targeting human glioblastoma multiforme cells

doi: 10.1186/s12967-024-04930-4

Figure Lengend Snippet: Proposed model of human GBM cell death mediated by ZIKV-LAV infection. A – D General virus infection life cycle. A ZIKV-LAV enters human GBM cells through Axl and integrin α v β 5 cellular receptors. B The ZIKV-LAV genome is translated to express viral proteins and the viral genome is replicated. C The viral genome and viral proteins assemble the nucleoprotein in preparation for ( D ) release of progeny into the surroundings with concomitant viral incorporation of host cell membrane. E Cellular and viral proteins expressed during ZIKV-LAV infection are also responsible for cell death in human GBM. F – G cleavage of caspase-3 leads to non-lytic or non-inflammatory cell death by apoptosis; H – I cleavage of gasdermin-D (GSDMD) leads to the formation of membrane pore complexes that shuttles inflammatory IL-1β outside of the cells. GSDMD cleavage also leads to inflammasome activation and lytic and inflammatory cell death by pyroptosis. Image created with BioRender.com

Article Snippet: The Human Protein Atlas report that Axl and integrin β 5 are highly expressed in neuroprogenitor cells (NPC) but not in terminally differentiated neurons [ , ], indicating that the GBM selectivity of ZIKV-LAV infection is partly explained by differential Axl and integrin α v β 5 expression.

Techniques: Infection, Virus, Membrane, Activation Assay